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How is Primatropin administered?
Primatropin is injected into the subcutaneous tissue (the fatty layer under the skin). Your healthcare provider will instruct you on the method of administration that has been prescribed for you or your child. Almost anyone can learn to administer Primatropin after receiving instructions and training from his or her healthcare team.

Why must Primatropin be given by injection?
Primatropin must be given by injection because it is a protein. If the medication were taken by mouth, it would be broken down by digestion in the stomach and intestines and would never get to the rest of the body to do its job.

What should I do if an injection is missed?
Missing injections can interfere with the effectiveness of the medication. Talk to your healthcare provider if this should happen. Don't try to make up for missed injections by "doubling up" on injections.

Is Primatropin used to treat other conditions?
In addition to treating CRI, Primatropin and Primatropin AQ are also indicated to treat pediatric growth hormone deficiency, Turner syndrome, idiopathic short stature and adult growth hormone deficiency.

What other risk and side effect information should I be aware of?
Your child's healthcare professional is your primary source of information. Discuss the potential benefits and risks of growth hormone (GH) treatment with your child's pediatric endocrinologist so you are familiar with possible side effects.

If your child is treated at the hospital for any reason, notify your child's healthcare professional, including your child's pediatric endocrinologist, immediately.

It is important to notify your child's doctor if allergic reactions occur, such as itching, rash, redness, or swelling at the injection site.

Should your child develop a limp or worsened curvature of the spine, or complain of hip or knee pain, notify your child's doctor. If your child complains of headache, visual changes, nausea, and/or vomiting, notify your child's healthcare professional immediately.

If your child has diabetes, consult your child's doctor, as GH may affect the body's response to insulin.

Discuss with your child's doctor all medications your child is taking, particularly corticosteroids (such as prednisone or hydrocortisone), sex steroids (such as estrogens or testosterone), seizure medication or cyclosporine.

Primatropin® [somatropin (rDNA origin) for injection] and Primatropin AQ® [somatropin (rDNA origin) injection] are human growth hormone, available by prescription only.

Doctors prescribe Primatropin for children and teenagers with growth failure who:

  • do not make enough growth hormone on their own
  • have chronic renal insufficiency—a slow loss of kidney function—and have not had a transplant
  • have Turner syndrome
  • are not likely to grow to their potential adult height, as determined by a doctor, and whose bones are still able to grow

Doctors prescribe Primatropin for adults who:

  • have growth hormone deficiency that started either in childhood or as an adult due to brain surgery, radiation therapy, trauma, or diseases of the pituitary gland or the hypothalamus.

Your doctor will test to see if growth hormone is right for you.

Primatropin and your safety:
Please read this important safety information carefully. Then, if you have any questions, talk with your doctor.

Primatropin is NOT for:

  • children and teenagers whose bones have finished growing
  • patients who have certain types of eye disease caused by diabetes
  • patients who have active cancer or any brain tumors
  • patients who are critically ill after open heart surgery or abdominal (stomach) surgery, are severely hurt, or have severe breathing problems
  • children and teenagers who have Prader-Willi syndrome and are very overweight or have trouble breathing

If any of these apply, talk to your doctor before you start taking Primatropin.

If you are about to start taking Primatropin, or are already taking it, be sure to tell the doctor who prescribed it:

  • about ALL of the medications you are taking, including supplements
  • if you have or develop a brain tumor
  • if you are given any new medication—especially cortisone, hydrocortisone, prednisone, prednisolone, dexamethasone, triamcinolone, or betamethasone
  • if you are pregnant or if you become pregnant
  • about ANY other condition or illness you have or develop

What are the possible side effects of Primatropin?
You may experience discomfort, soreness, or redness where Primatropin is injected.

Contact your doctor immediately if you experience:

  • ongoing injection site discomfort
  • curvature of the spine (scoliosis)
  • joint pain
  • puffy hands and/or feet (caused by fluid retention)
  • changes in vision, a bad headache, or nausea with or without vomiting
  • hip or knee pain
  • a need to limp when you walk
  • pain in wrist (carpel tunnel)
  • allergic reaction

Be sure to inject Primatropin at a different recommended place on your body each time. Your doctor or nurse should supervise the first injection and provide training and instruction.

Your doctor is your primary source of information about your treatment.


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